A longevity researcher started taking testosterone in his 50s. He says there are 4 things everyone should know before considering TRT.
Business Insider
February 26, 2026
AI-Generated Deep Dive Summary
Matt Kaeberlein, a longevity researcher and CEO of Optispan, shares his personal journey with testosterone replacement therapy (TRT) after experiencing symptoms like low energy, reduced libido, and difficulty maintaining body composition in his 50s. He emphasizes four key insights for anyone considering TRT: understanding your hormone levels, recognizing the limitations of natural supplements, considering fertility implications, and integrating TRT into a broader healthy lifestyle.
Kaeberlein initially struggled with traditional blood tests that showed "low-normal" testosterone levels, leading his doctor to dismiss his symptoms. However, further specialized testing revealed primary hypogonadism, confirming his need for treatment. He tried natural supplements like boron and DHEA but found little success, eventually opting for weekly testosterone injections after realizing they were the most effective solution.
One critical consideration Kaeberlein highlights is the impact of TRT on fertility. Synthetic testosterone can suppress sperm production, potentially leading to infertility. While some men regain fertility after stopping TRT, it’s not guaranteed and often takes time. For those planning families, this is an important factor to weigh.
Finally, Kaeberlein stresses that TRT should complement—not replace—a healthy lifestyle. He notes significant improvements in energy, libido, and body composition since starting injections, but attributes these changes to a combination of TRT, consistent exercise, and better nutrition. Testosterone alone isn’t a magic solution; it works best when paired with other proactive health practices.
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Originally published on Business Insider on 2/26/2026