Africa: HIV Studies Call for Africa-Specific Data to Optimise Treatment Strategies
AllAfrica
February 26, 2026
AI-Generated Deep Dive Summary
New HIV research presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2026) has highlighted critical gaps in evidence that亟需 urgent attention to improve HIV treatment strategies across Africa. Studies from theNdovu and Sungura projects, led by researchers at the University of Nairobi’s Centre for Epidemiological Modelling and Analysis (CEMA), emphasize the importance of generating locally relevant data tailored to African contexts. These studies focus on vulnerable populations, including children, adults with persistent viraemia, and older individuals living with HIV.
The Ndovu study revealed that 41% of children and adolescents on dolutegravir (DTG)-based regimens failed to achieve viral suppression after three months despite adherence counselling. This finding underscores a significant evidence gap in identifying effective interventions for young patients experiencing DTG treatment failure. Additionally, the study challenges current WHO guidelines, which recommend switching to protease inhibitor-based regimens after two consecutive high viral load results. The Ndovu research suggests that some patients may be able to re-suppress the virus with adherence support alone, potentially reducing unnecessary treatment switches.
The Sungura study evaluated the effectiveness of switching older adults from B/F/TAF to DTG/3TC therapy, demonstrating 100% viral suppression among participants at week 48. However, it also highlighted the high burden of co-morbidities such as kidney disease and diabetes in aging populations living with HIV, emphasizing the need for tailored treatment approaches. These findings challenge the one-size-fits-all approach to HIV care and underscore the importance of considering local factors when developing treatment guidelines.
Dr. Loice Ombajo, chief investigator of
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Originally published on AllAfrica on 2/26/2026