Alzheimer's gene boosts seizures, but pathway can be targeted, study finds
Medical Xpress
February 16, 2026
The gene most strongly correlated with Alzheimer's disease also boosts seizure activity by decreasing levels of ion pumps and energy-producing enzymes in neurons, a new study by researchers at the University of Illinois Urbana-Champaign has found. Furthermore, the energy-making pathway was stimulated and seizures reduced in mouse models of Alzheimer's disease by administration of a blood pressure medication, pointing to a potential treatment to reduce seizure activity in those with the gene, APOE4.
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Originally published on Medical Xpress on 2/16/2026