Cannabis in pregnancy may leave schizophrenia-risk signals in the placenta
Medical Xpress
February 25, 2026
AI-Generated Deep Dive Summary
Cannabis use during pregnancy has been linked to signals in the placenta that may increase the risk of schizophrenia in offspring. A recent study highlights that exposure to cannabis during pregnancy alters molecular signaling in the placenta, potentially disrupting fetal brain development. Schizophrenia, a severe mental disorder characterized by psychosis and cognitive impairments, affects approximately 1% of Canadians and is associated with significant health challenges, including reduced life expectancy.
The placenta plays a critical role in nutrient exchange between mother and fetus, as well as protecting the developing baby from harmful substances. The study found that cannabis exposure during pregnancy may interfere with this vital function by disrupting cellular signaling pathways. These disruptions could potentially impact fetal brain development, increasing vulnerability to schizophrenia later in life. Researchers emphasize that while genetic factors also play a role in schizophrenia risk, environmental influences during pregnancy, such as cannabis use, can significantly contribute to the disease trajectory.
Schizophrenia is not only a serious mental health condition but also a leading cause of disability worldwide. It often emerges in early adulthood and is linked to challenges such as social isolation, unemployment, and higher rates of mortality. The study underscores the importance of understanding how environmental factors during pregnancy, including substance use, can leave lasting imprints on fetal development.
For expectant mothers, this research serves as a reminder of the potential risks associated with cannabis use during pregnancy. While more studies are needed to fully understand the long-term effects, the findings suggest that reducing exposure to harmful substances is crucial for safeguarding offspring’s mental health. Health professionals should consider emphasizing the importance of avoiding cannabis and other substances during pregnancy to mitigate these risks.
Overall, this research adds to a growing
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Originally published on Medical Xpress on 2/25/2026