Christina Applegate reveals she is largely confined to bed due to multiple sclerosis

The Guardian World

by Sian Cain

February 26, 2026

AI-Generated Deep Dive Summary

Christina Applegate has opened up about her battle with multiple sclerosis (MS), revealing that she is now largely confined to bed due to the debilitating effects of the disease. In an interview with *People* magazine ahead of her memoir’s release, the 54-year-old actress shared that her days are often spent resting in bed because of the pain associated with movement. Despite her physical limitations, Applegate expressed gratitude for small joys, such as taking her 15-year-old daughter to school, which she describes as her favorite activity. Her candid remarks highlight the challenges of living with MS while maintaining a sense of normalcy and connection. Multiple sclerosis is a chronic neurological condition that affects the central nervous system, leading to symptoms like fatigue, pain, and mobility issues. Applegate was diagnosed in 2021, and her experience underscores how the disease can profoundly impact daily life. While some patients may manage their symptoms effectively, others face significant limitations, as is the case with Applegate. Her openness about her condition not only sheds light on the personal struggles of living with MS but also serves as a reminder of the importance of understanding and supporting those who battle the disease. The actress’s memoir, *You With the Sad Eyes*, offers further insight into her life and experiences with MS. An upcoming extract in *The Guardian* is expected to delve deeper into her journey, providing readers with a more comprehensive understanding of her challenges and resilience. Applegate’s story resonates not only with fans of her acting career but also with anyone seeking to better understand the realities of living with chronic illness. From a global perspective, Applegate’s openness about her health struggles aligns with growing conversations around mental and physical wellness. Her ability to find joy in simple moments despite her limitations serves as an inspiration to others facing similar challenges. By sharing her story, she contributes to a broader dialogue about the impact of chronic illnesses like MS and the need for greater awareness and support systems for patients worldwide. In a world where health issues are often kept private, Applegate’s willingness to speak openly about her condition makes her a powerful voice in the fight against MS. Her experience highlights the importance of empathy and understanding in addressing the invisible struggles faced by those with chronic illnesses.

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Originally published on The Guardian World on 2/26/2026