Daily briefing: ‘Universal’ vaccine protects mice from multiple pathogens

Nature

by Jacob Smith

February 25, 2026

AI-Generated Deep Dive Summary

A groundbreaking nasal-spray vaccine has shown promise in protecting mice from a variety of bacterial and viral pathogens, including SARS-CoV-2, as well as respiratory allergens. Unlike traditional vaccines that target the adaptive immune system, this spray activates the innate immune system, offering broader protection due to its generalized reactivity. If proven safe and effective in humans, such a "universal vaccine" could provide long-lasting immunity, potentially revolutionizing pandemic preparedness by offering a first line of defense against emerging pathogens. In another significant development, researchers have identified a simple blood test that measures abnormal tau protein levels, which could predict the onset of Alzheimer’s disease. This test not only serves as a molecular clock to determine an individual's risk but also offers a potential biomarker for earlier intervention, when treatments are more effective. If validated in larger studies, this breakthrough could transform Alzheimer’s research by streamlining clinical trials and enabling earlier therapeutic interventions. The National Science Foundation (NSF) is set to undergo a notable shift with the nomination of Jim O’Neill, a biotechnology investor without a scientific background, as its next leader. This decision has sparked concerns within the scientific community, as it marks a departure from the organization's historical focus on scientific expertise. The appointment could reshape NSF priorities and funding decisions, potentially altering the trajectory of U.S. science policy. Global military budget increases are reshaping the landscape of scientific research and collaboration. Countries like China, the United States, and NATO members are directing a growing portion of their defense funds toward research

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Originally published on Nature on 2/25/2026