Engineered bacteria can consume tumors from the inside out
Phys.org
February 24, 2026
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Engineered bacteria capable of consuming tumors from the inside out could revolutionize cancer treatment. A research team at the University of Waterloo has developed a groundbreaking approach using hungry bacteria that target and destroy tumors by exploiting their unique environment. These bacteria spores enter the tumor, thriving in nutrient-rich, low-oxygen conditions—preferences that make them ideal for attacking cancer cells. As they feed on the nutrients within the tumor, the bacteria grow and colonize the central space of the tumor, effectively eliminating it from the body.
The innovation lies in the bacteria's ability to specifically target tumors while sparing healthy tissues. Unlike traditional treatments such as chemotherapy or radiation, which can harm surrounding areas, this method focuses solely on the tumor. Dr. Marc Aucoin, a chemical engineering professor at Waterloo, explained that the bacteria are naturally drawn to environments with abundant nutrients and minimal oxygen, making them well-suited for infiltrating and degrading tumors.
This approach has the potential to offer a non-invasive alternative to current cancer therapies. By targeting the tumor's core, the bacteria can break it down from within, reducing or even eliminating the need for surgery or other more invasive procedures. The research also highlights the promise of using engineered organisms in medicine, offering a novel perspective on treating diseases at their source.
The significance of this breakthrough lies in its potential to improve patient outcomes and reduce the side effects associated with conventional cancer treatments. As the bacteria focus solely on the tumor, they minimize harm to healthy cells, potentially leading to fewer complications and a more effective treatment overall. This development marks an exciting step forward in the fight against cancer, showcasing the power of innovative biotechnological solutions.
While still in early stages of research, this method demonstrates the potential for bacteria-based therapies to transform oncology. By leveraging the natural preferences of these microscopic organisms, scientists are opening new avenues for tackling one of humanity
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Originally published on Phys.org on 2/24/2026