Expands the genetic alphabet: Artificial DNA base pair uses halogen bonds to form stable structures
Phys.org
February 19, 2026
AI-Generated Deep Dive Summary
For the first time, scientists have developed an artificial DNA base pair that uses halogen bonds instead of the natural hydrogen bonds found in conventional DNA. This groundbreaking advancement opens new possibilities for genetic engineering and synthetic biology by demonstrating that alternative chemical forces can form stable DNA structures. The study, published in *Journal of the American Chemical Society*, highlights how these halogen bonds act as precise "docking sites" between molecules, enabling the creation of custom DNA systems with unique properties.
Natural DNA relies on hydrogen bonds to hold its base pairs together, which are relatively weak compared to other chemical interactions. In this new approach, researchers utilized halogen bonds—stronger and more directional forces—to create a synthetic base pair. This innovation not only challenges the traditional understanding of DNA stability but also proves that non-natural forces can support viable genetic structures. The research marks a significant milestone in designing artificial DNA systems with tailored functionalities.
The implications of this discovery are vast, particularly for fields like medicine and biotechnology. By expanding the genetic alphabet, scientists could develop new tools for gene editing, drug delivery, or even create entirely novel materials with DNA-like frameworks. This breakthrough also deepens our understanding of how different chemical interactions can influence molecular recognition and self-assembly.
Ultimately, this study pushes the boundaries of synthetic biology by showing that DNA doesn’t need to rely solely on hydrogen bonds. The ability to engineer alternative base pairs using halogen bonds could lead to unprecedented control over genetic structures and their functions, paving the way for innovative applications in science and technology.
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Originally published on Phys.org on 2/19/2026