Genetics helps explain who gets the 'telltale tingle' from music, art and literature
Medical Xpress
February 23, 2026
AI-Generated Deep Dive Summary
A groundbreaking study by Giacomo Bignardi and colleagues from Max Planck Institute for Psycholinguistics reveals that genetics play a significant role in determining whether individuals experience the "telltale tingle"—a physical response like chills or goosebumps—when exposed to music, art, or literature. Published in *PLOS Genetics*, the research highlights how specific gene regions influence emotional responses to aesthetic experiences, offering new insights into the biological underpinnings of art and music appreciation.
The study utilized twin analyses to identify correlations between genetic variations and subjective emotional reactions. Researchers found that certain genes associated with dopamine regulation and brain function, particularly in the prefrontal cortex, were linked to heightened sensory experiences. These findings suggest that individuals may inherit a predisposition to feel strong emotional responses to art and music, which could explain why some people are more likely to experience chills or goosebumps.
Understanding these genetic influences not only deepens our knowledge of human emotions but also has broader implications for health and well-being. The research underscores the interconnectedness of genetics, brain function, and aesthetic experiences, potentially aiding in the development of interventions for emotional processing disorders. For readers interested in health, this study provides a fascinating glimpse into how our genes shape our ability to connect with art and music on a profound level.
Moreover, the findings emphasize the importance of considering genetic factors when exploring individual differences in emotional responses. This could lead to more personalized approaches in education, therapy, or even artistic creation. By unraveling the genetic basis of such experiences, scientists may pave the way for new strategies to enhance emotional well-being and foster a deeper understanding of human creativity and expression.
In summary, this study bridges the gap between genetics and aesthetic
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Originally published on Medical Xpress on 2/23/2026