Health effects linger 20 generations after rats are exposed to fungicide

Nature

by Rachel Fieldhouse

February 26, 2026

AI-Generated Deep Dive Summary

A groundbreaking study reveals that exposure to a fungicide caused long-lasting health issues spanning 20 generations of rats. The research highlights the persistence of epigenetic changes, which are modifications to gene expression without altering DNA itself. These changes led to increased risks of kidney disease, obesity, and birthing complications in descendants up to the twentieth generation. The study focused on vinclozolin, a fungicide that has been widely used but is now banned in several countries due to its harmful effects. By exposing pregnant rats to this chemical, researchers observed that these epigenetic changes were passed down through generations. Unlike previous studies, which primarily examined directly exposed individuals, this research tracked the effects on subsequent generations, uncovering a surprising pattern of heritable health issues. The methodology involved exposing an initial group of rats and breeding them for 23 generations. Advanced sequencing techniques showed that methylation patterns—chemical markers affecting gene expression—persisted across generations. These changes were linked to increased disease rates in organs like the kidneys and ovaries, as well as higher instances of obesity and birthing problems. Experts emphasize the significance of these findings for human health. While similar studies have shown that environmental exposures can impact future generations, this research underscores the potential risks of chemical exposure over time. The results serve as a cautionary tale about the long-term consequences of environmental pollutants and the need for stricter regulations on harmful chemicals. This study not only advances our understanding of epigenetics but also raises important questions about public health policies. As society grapples with the growing impact of environmental toxins, such research calls for greater vigilance in managing chemical exposures to protect future generations from unseen threats.

Verticals

scienceresearch

Originally published on Nature on 2/26/2026