Houston vs. Colorado odds, prediction: 2026 college basketball picks for February 28 from proven model

CBS Sports
by Daniel Lewis
February 28, 2026
AI-Generated Deep Dive Summary
Houston vs. Colorado odds, prediction: 2026 college basketball picks for February 28 from proven model
The fifth-ranked Houston Cougars face the Colorado Buffaloes in a crucial Big 12 matchup on February 28 at the Fertitta Center. Despite Houston's strong overall record (23-5) and their position as a top contender for a NCAA Tournament top-two seed, they enter this game on a three-game losing streak against tough opponents like Kansas, Iowa State, and Arizona. Meanwhile, Colorado is looking to secure a signature win to bolster its own postseason hopes, with a 16-12 record overall and 6-9 in conference play. The Cougars are heavy favorites, listed as 19.5-point favorites with an over/under of 139.5 points. SportsLine's Projection Model has simulated the game 10,000 times and predicts a high-scoring affair, favoring the "over" on the total points. Houston’s recent struggles have raised questions about their ability to maintain momentum in a competitive Big 12 conference. While they remain a strong team overall, their inability to secure wins against top-tier opponents has created an opening for Colorado to potentially pull off an upset. The Buffaloes, averaging over 80 points per game but allowing around 77, could capitalize on Houston's vulnerabilities
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Originally published on CBS Sports on 2/28/2026