How the brain suppresses itch during stress
Medical Xpress
February 23, 2026
AI-Generated Deep Dive Summary
Researchers at the Indian Institute of Science (IISc) have identified a neural circuit in the brain that explains how stress influences itching. Their study, published in *Cell Reports*, reveals that specific neurons activated during stressful situations can directly regulate the sensation of itch, shedding light on the complex interplay between mental and physical sensations.
The research highlights the role of a particular type of neuron located in the brain's prefrontal cortex, which becomes active under stress. These neurons send signals to the spinal cord, effectively modulating the transmission of itch-inducing signals from the skin to the brain. This discovery underscores how stress can alter our perception of physical discomfort, potentially offering new avenues for treating conditions like chronic itching or anxiety-related skin disorders.
Understanding this neural circuit could lead to innovative therapies targeting these specific neurons to alleviate symptoms in individuals suffering from conditions such as eczema or neuropathic pain. The findings also emphasize the importance of addressing psychological stress in managing physical sensations, highlighting the interconnectedness of mind and body in health and disease.
For readers interested in health, this research provides insights into how mental states can influence physical sensations and opens doors for more personalized approaches to treating conditions where itch and stress intersect. It reinforces the idea that holistic approaches, combining both mental and physical care, may be key to effective treatment.
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Originally published on Medical Xpress on 2/23/2026