How ultrasound is delivered matters when opening the blood-brain barrier

Medical Xpress
March 2, 2026
Focused ultrasound combined with microbubbles is increasingly being used to safely and reversibly open the blood-brain barrier (BBB) for the treatment of brain tumors and neurodegenerative disorders. While much attention has been placed on acoustic pressure and total exposure time, less is known about how the temporal structure of ultrasound delivery influences microbubble activity.
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Originally published on Medical Xpress on 3/2/2026