Human Brain Cells On a Chip Learned To Play Doom In a Week

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by BeauHD

February 28, 2026

Researchers at Cortical Labs used living human neurons grown on a chip to learn how to play Doom in about a week. "While its performance is not up to par with humans, experts say it brings biological computers a step closer to useful real-world applications, like controlling robot arms," reports New Scientist. From the report: In 2021, the Australian company Cortical Labs used its neuron-powered computer chips to play Pong. The chips consisted of clumps of more than 800,000 living brain cells grown on top of microelectrode arrays that can both send and receive electrical signals. Researchers had to carefully train the chips to control the paddles on either side of the screen. Now, Cortical Labs has developed an interface that makes it easier to program these chips using the popular programming language Python. An independent developer, Sean Cole, then used Python to teach the chips to play Doom, which he did in around a week. "Unlike the Pong work that we did a few years ago, which represented years of painstaking scientific effort, this demonstration has been done in a matter of days by someone who previously had relatively little expertise working directly with biology," says Brett Kagan of Cortical Labs. "It's this accessibility and this flexibility that makes it truly exciting." The neuronal computer chip, which used about a quarter as many neurons as the Pong demonstration, played Doom better than a randomly firing player, but far below the performance of the best human players. However, it learnt much faster than traditional, silicon-based machine learning systems and should be able to improve its performance with newer learning algorithms, says Kagan. However, it's not useful to compare the chips with human brains, he says. "Yes, it's alive, and yes, it's biological, but really what it is being used as is a material that can process information in very special ways that we can't recreate in silicon." Cortical Labs posted a YouTube video showing its CL1 biological computer running Doom. There's also source code available on GitHub, with additional details in a README file. Read more of this story at Slashdot.

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Originally published on Slashdot on 2/28/2026