Immune cells retain a 'molecular memory' of their tissue location, study shows
Medical Xpress
March 2, 2026
A new AI-based method reconstructs spatial information about where immune cells were originally located in an organ, even after these cells have been removed from the tissue and analyzed individually. To accomplish this, researchers at the University Hospital Bonn (UKB) and the University of Bonn use the transcriptome, i.e., the entirety of all messenger RNA transcripts produced by genes within a cell at a given time. The work has been published in the journal Advanced Science and introduces the new MERLIN algorithm.
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Originally published on Medical Xpress on 3/2/2026