New GLP-1 pill orforglipron outperforms oral semaglutide in yearlong diabetes trial
Medical Xpress
February 26, 2026
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A groundbreaking study published in *The Lancet* reveals that orforglipron, a novel GLP-1 receptor agonist (RA) pill, outperforms oral semaglutide in managing type 2 diabetes. The phase 3 randomized controlled trial found that orforglipron achieved greater reductions in blood sugar levels and body weight compared to semaglutide over the course of one year. This advancement marks a significant step forward in diabetes treatment, offering a more effective option for patients seeking better glucose control and weight management.
GLP-1 receptor agonists are a class of medications known for their ability to mimic the effects of glucagon-like peptide-1, a hormone that stimulates insulin secretion and slows gastric emptying. These drugs have become a cornerstone in diabetes management due to their dual benefits of lowering blood sugar and promoting weight loss. While semaglutide is already a leading oral GLP-1 RA, orforglipron’s superior performance in this trial suggests it may offer an improved alternative for patients.
The study involved over 900 participants with type 2 diabetes across multiple countries. Results showed that those taking orforglipron experienced an average reduction in HbA1c (a measure of blood sugar control) of 1.4%, compared to 1.1% for semaglutide. Additionally, orforglipron demonstrated better tolerability, with fewer participants discontinuing the trial due to adverse effects. This highlights its potential as a safer and more effective treatment option.
The significance of these findings cannot be overstated. For patients struggling with type 2 diabetes, improved blood sugar control is crucial in preventing complications such as cardiovascular disease and kidney damage. The greater weight loss observed with orforglipron also aligns with the growing recognition of obesity’s role in diabetes progression. By addressing both glucose management and body weight, this new drug could play a vital role in holistic diabetes care.
As researchers continue to explore innovative treatments for diabetes, orforglipron represents a promising development in the field. Its performance in clinical trials positions it as a potential game-changer in the management of type 2 diabetes, offering patients a more effective and well-tolerated option compared
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Originally published on Medical Xpress on 2/26/2026