Novel markers of brain blood flow and oxygenation may offer early clues to Alzheimer's risk
Medical Xpress
February 24, 2026
AI-Generated Deep Dive Summary
Scientists have identified subtle changes in brain blood flow and oxygen usage as potential early indicators of Alzheimer's disease risk, according to groundbreaking research from the Mark and Mary Stevens Neuroimaging and Informatics Institute at the Keck School of Medicine of USC. These novel markers could offer a non-invasive way to detect Alzheimer's before symptoms appear, potentially revolutionizing early intervention strategies.
The study highlights that even minor disruptions in how blood flows through brain vessels and how tissues utilize oxygen may be closely tied to Alzheimer's progression. This connection suggests that subtle changes in these physiological processes could serve as critical warning signs for the disease. Early detection is crucial because it allows for timely intervention, which may slow or prevent the onset of symptoms.
Researchers emphasize that current diagnostic methods often focus on identifying symptoms rather than underlying causes. By measuring brain blood flow and oxygenation patterns, scientists can gain deeper insights into how Alzheimer's develops at its earliest stages. This approach could help bridge the gap between symptom observation and disease prevention.
The findings align with growing evidence that vascular health plays a significant role in brain function and neurodegenerative diseases. Poor blood flow and inadequate oxygen delivery to brain tissue may contribute to the buildup of amyloid-beta plaques, a hallmark of Alzheimer's pathology. Understanding these relationships could pave the way for new therapies aimed at improving cerebral blood flow and reducing disease risk.
This research underscores the importance of maintaining good vascular health to protect against Alzheimer's. By monitoring brain blood flow and oxygenation, doctors may one day be able to identify individuals at higher risk and implement targeted preventive measures. Such advancements could have profound implications for public health, offering a promising new direction in the fight against Alzheimer's disease.
Overall, these discoveries mark a significant step forward in understanding the complex interplay between brain physiology and neurodegenerative diseases. As researchers continue to explore these markers, they may unlock
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Originally published on Medical Xpress on 2/24/2026