Osteoporosis drug shows potential against diseases caused by excess iron
Medical Xpress
February 23, 2026
AI-Generated Deep Dive Summary
Researchers at the University of São Paulo (USP) in Brazil have uncovered a groundbreaking potential use for two osteoporosis drugs—etidronate and tiludronate—in treating diseases caused by excess iron accumulation in the body. In their study, published in the journal *BioMetals*, the researchers demonstrated that these medications can bind to surplus iron, reduce oxidative stress, and protect cells from damage. This discovery opens a new avenue for addressing conditions linked to iron overload, such as hemochromatosis and anemia-related complications.
Iron is essential for bodily functions, but its excess can lead to severe health issues. Diseases caused by iron accumulation often lack effective treatments, making this finding particularly significant. The drugs in question are known for their ability to chelate metals, a property that has been repurposed to target iron instead of calcium, which is typically the focus in bone diseases. This unique mechanism allows them to neutralize excess iron without harming surrounding cells.
The study highlights how these osteoporosis medications could be repurposed for treating iron overload disorders. By targeting iron directly, they offer a potential alternative to existing treatments that may not be as effective or have more side effects. The researchers tested the drugs on human cells and found they successfully reduced oxidative stress, which is often a root cause of damage in iron-related diseases.
This breakthrough is especially promising for patients with limited treatment options for iron overload conditions. If further studies confirm these findings, etidronate and tiludronate could become valuable tools in managing diseases like hemochromatosis and other iron-associated disorders. The ability to repurpose existing drugs not only accelerates the development of new treatments but also reduces costs and time typically associated with creating entirely new medications.
The research underscores the importance of exploring alternative uses for approved drugs, potentially opening doors to innovative therapies for a range of health conditions. For those affected by iron overload diseases, this discovery could herald a more effective and safer treatment option
Verticals
healthmedical
Originally published on Medical Xpress on 2/23/2026