Popular brain supplement linked to shorter lifespan in men
Science Daily
February 26, 2026
AI-Generated Deep Dive Summary
A groundbreaking study published in *Aging-US* reveals a surprising connection between tyrosine levels and lifespan, particularly among men. Researchers analyzed data from over 270,000 participants in the UK Biobank and found that higher blood levels of tyrosine—an amino acid linked to brain function and often marketed as a supplement for focus and mental performance—were associated with shorter life expectancy in men. The study suggests that men with elevated tyrosine levels could live nearly one year less on average compared to those with lower levels, while no significant association was found in women.
The research highlights the importance of understanding how amino acids like tyrosine influence aging and longevity. Tyrosine plays a key role in producing neurotransmitters such as dopamine, which affect mood, motivation, and cognitive performance. Despite its popularity as a supplement, this study raises questions about its long-term impact on health, particularly for men. The findings also point to potential biological differences between sexes that could influence aging outcomes.
The study utilized both observational data and genetic techniques to examine the relationship between tyrosine and overall mortality. After adjusting for other factors like phenylalanine, researchers found a consistent link between higher tyrosine levels and reduced life expectancy in men. This suggests that tyrosine itself may independently affect aging processes, particularly through pathways related to insulin resistance and stress-related neurotransmitters.
While the study does not directly test the effects of tyrosine supplements, it encourages individuals with naturally high tyrosine levels to consider dietary adjustments, such as moderating protein intake, to potentially support healthier aging. The research underscores the need for further investigation into how diet, lifestyle, and biological sex interact to influence lifespan and age-related diseases.
This discovery adds an important layer of complexity to our understanding of amino acids and their role in longevity. It also raises intriguing questions about why men appear more sensitive to tyrosine's effects than women, potentially contributing to the longstanding gap in average lifespan between the sexes. As scientists continue to explore these connections, the findings could pave the way for personalized approaches to aging that account for sex differences and nutrient levels.
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Originally published on Science Daily on 2/26/2026