Preclinical or clinical? New obesity definition could reshape diagnosis and prevention
Medical Xpress
February 23, 2026
AI-Generated Deep Dive Summary
A new study challenges traditional views of obesity by emphasizing the importance of biomarkers beyond body mass index (BMI) in defining and diagnosing the condition. Researchers led by Prof. Matthias Schulze from the German Institute of Human Nutrition found that nearly all individuals with a BMI of 30 kg/m² or higher exhibit additional indicators of excess body fat, such as increased visceral fat or metabolic disturbances. Moreover, approximately 80% of those classified as obese are already experiencing health complications, including cardiovascular issues, type 2 diabetes, or other related conditions. These findings, published in *Nature Communications*, highlight the need for a more nuanced approach to obesity diagnosis and prevention.
The study distinguishes between preclinical and clinical obesity, where preclinical obesity refers to individuals with BMI above 30 but without overt health complications, while clinical obesity involves those with additional metabolic or organ-related issues. This distinction is critical because it suggests that many people classified as obese under traditional BMI criteria are already at significant risk of disease. By identifying biomarkers like fat distribution and metabolic changes, healthcare providers can better assess an individual’s health status and intervene earlier.
The implications of this research are profound for public health and clinical practice. Early identification of preclinical obesity could lead to more personalized prevention strategies, such as lifestyle interventions or targeted medical treatments, to reduce the risk of developing serious complications. This shift in perspective also underscores the complexity of obesity as a multifaceted condition influenced by factors like genetics, environment, and metabolic health.
For readers interested in health and medicine, this study emphasizes the importance of moving beyond BMI as the sole indicator of obesity. By focusing on additional biomarkers, healthcare professionals can more accurately assess an individual’s risk of chronic diseases and implement targeted interventions. This approach could ultimately improve outcomes for millions of people struggling with weight-related health issues.
This research not only reshapes our understanding of obesity but also opens new avenues for prevention and treatment. By prioritizing early detection and personalized care, it
Verticals
healthmedical
Originally published on Medical Xpress on 2/23/2026