Psychedelics may work by shutting down reality and unlocking memory
Science Daily
February 15, 2026
AI-Generated Deep Dive Summary
Psychedelic substances may work by altering brain activity in ways that shift perception from the external world to internal memory networks. According to a new study, these compounds bind to serotonin receptors, particularly the 2A receptor, which reduces visual processing and encourages the brain to draw on stored memories. This process can lead to hallucinations as the mind fills gaps in sensory input with vivid fragments from memory, creating an altered state of consciousness.
The research reveals that psychedelics increase slow, rhythmic brain waves in visual areas, which stimulate the retrosplenial cortex—a key region for accessing stored memories. These oscillations disrupt normal communication between brain regions, weakening awareness of external events and strengthening reliance on internal recollection. This shift mimics a dreaming-like state while awake, where perception is shaped by memory rather than direct sensory input.
Using advanced imaging techniques, scientists observed these changes in real time by tracking fluorescent signals in the brains of specially engineered mice. The findings show that psychedelics alter neural activity patterns, particularly in cortical layers responsible for interregional communication. These disruptions temporarily redirect the brain’s focus from external stimuli to internal memory networks, creating a unique state of perception.
The implications of this study extend beyond understanding hallucinations; it also sheds light on the potential therapeutic uses of psychedelics. By shifting brain activity patterns, these substances may help individuals access positive memories and restructure negative thought patterns under medical supervision. This could pave the way for innovative treatments for conditions like depression and anxiety, where recalling and reframing past experiences is crucial.
Overall, this study provides a deeper understanding of how psychedelics alter perception and memory recall, offering insights into their therapeutic potential. For readers interested in neuroscience and mental health, these findings highlight the complex interplay between brain activity, memory, and consciousness—opening new avenues for exploring the mind’s inner workings.
Verticals
scienceresearch
Originally published on Science Daily on 2/15/2026