Publisher Correction: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling

Nature

by Jay Xiaojun Tan

February 20, 2026

AI-Generated Deep Dive Summary

A recent correction to a study published in *Nature* addresses errors in the labeling of specific phosphoinositides in Figure 5 of the original article. The study originally identified PtdIns(3,5)P2 as an endogenous ligand of STING, a protein involved in innate immune signaling. This discovery highlights its role in antiviral responses and immune regulation. The correction clarifies mislabeled sections in Figure 5f, g, and h, ensuring accurate representation of the phosphoinositides discussed. These corrections maintain the study's overall conclusions about PtdIns(3,5)P2's function as a key ligand for STING, underscoring its importance in immune signaling. Accurate scientific communication is crucial, particularly when detailing molecular mechanisms like those involving STING and phosphoinositides. This study contributes to our understanding of how these lipids regulate immune responses, offering insights into potential therapeutic targets for infections or autoimmune diseases. The correction emphasizes the need for meticulous attention to detail in scientific publishing. Such corrections help maintain the integrity of research findings, ensuring that future studies build on a solid foundation of accurate data. In summary, while the correction is technical, it reinforces the study's broader implications for innate immunity and antiviral therapies. Researchers studying immune signaling can rely on this corrected work to guide further investigations into phosphoinositides' roles in health and disease.

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Originally published on Nature on 2/20/2026