Rare genetic variant protects against malaria-causing parasite by making red blood cells bigger
Medical Xpress
February 23, 2026
AI-Generated Deep Dive Summary
Scientists have uncovered a rare genetic variant, rs112233623-T, which provides natural protection against malaria by altering the size and function of red blood cells. This variant reduces the activity of CCND3, a gene responsible for regulating red blood cell division and growth. As a result, individuals with this variant produce fewer but larger-than-normal red blood cells. Additionally, the variant increases levels of reactive oxygen species (ROS) within these cells, creating an environment hostile to malaria parasites.
The study highlights how this genetic change disrupts the malaria parasite's ability to thrive and replicate inside red blood cells. Larger cell size and elevated ROS levels make it harder for the parasite to survive, effectively reducing its chances of infecting the host. This mechanism underscores the intricate relationship between genetics, cellular biology, and disease resistance.
Understanding this natural defense mechanism could have significant implications for malaria prevention and treatment. Researchers hope that this discovery could lead to new therapies or preventive strategies inspired by the body's own protective mechanisms. For individuals in high-risk areas, knowing whether they carry this genetic variant could be valuable for personalized approaches to combat malaria.
The findings also emphasize the importance of studying how genetic variations influence disease susceptibility. By unraveling these complex interactions, scientists may unlock novel ways to fight infectious diseases like malaria. This research not only advances our knowledge of genetics and cell biology but also offers hope for improved global health outcomes.
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Originally published on Medical Xpress on 2/23/2026