Reinforced enzyme expression drives high production of durable lactate-based polyester
Phys.org
February 25, 2026
AI-Generated Deep Dive Summary
A groundbreaking study reveals how enhancing enzyme expression in a recombinant strain of *Cupriavidus necator* significantly boosts the production of lactate-based polyesters, specifically Poly[(D-lactate)-co-(R)-3-hydroxybutyrate] (LAHB). By reinforcing the gene responsible for the lactate-polymerizing enzyme, researchers achieved a higher lactate content in the polymer, which improved its durability and mechanical properties. The resulting LA-enriched material maintained a high molecular weight while balancing strength and elongation comparable to conventional polyethylene, making it a promising eco-friendly alternative to fossil-derived plastics.
Bio-based polyhydroxyalkanoates (PHAs) are celebrated for their sustainability and biodegradability, offering a viable solution to the global plastic pollution crisis. LAHB, in particular, is an environmentally friendly microbial copolyester whose properties are heavily influenced by its lactate content. Higher lactate fractions enhance material strength and elongation while retaining biodegradability, making it suitable for various industrial applications.
The study utilized *Cupriavidus necator*, a well-known microbe for PHA production, to engineer a recombinant strain with reinforced enzyme expression. This genetic modification not only increased lactate incorporation but also ensured the polymer retained its high molecular weight and mechanical integrity. The findings demonstrate that tailored enzyme expression can optimize bio-based polymers, paving the way for scalable and sustainable plastic alternatives.
This advancement is significant for industries seeking eco-conscious materials without compromising on performance. By improving the properties of LAHB, researchers have moved a step closer to replacing traditional plastics with biodegradable, renewable options. This breakthrough highlights the potential of microbial engineering in developing next-generation sustainable materials, offering hope for a greener future.
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Originally published on Phys.org on 2/25/2026