Resident Evil Requiem's The Final Puzzle may be the most convoluted challenge to grace Capcom's series, and no one's figured out the answer yet
PC Gamer
by Elie Gould February 26, 2026
AI-Generated Deep Dive Summary
Resident Evil Requiem’s The Final Puzzle challenge has left players scratching their heads, as it remains unsolved even after extensive playthroughs. This enigmatic puzzle revolves around a mysterious DNA sequence revealed by examining the Severed Hand item under a microscope: GGC AAG AUA UGU CAU, accompanied by the cryptic message “Let’s play.” The sequence hints at an intricate connection between letters and astronomical distances, with clues hidden in other items like the hourglass and notes scattered throughout the game. For instance, the hourglass reveals “U = 380,000,” linking U to the Moon, while a note mentions “C = 4.2 ly” for the nearest star and another clue ties G to the Sun’s distance. These symbols correspond to letters in the DNA sequence, but decoding them is no easy feat.
The challenge requires players to meticulously track every item and clue across multiple stages of the game. While other puzzles in Requiem are straightforward, The Final Puzzle demands meticulous attention to detail and repeated playthroughs. Players must decipher clues like the roulette wheel patterns in Rhodes Hill Hospital’s Parlor and interpret cryptic messages, such as “Let the sweet pair hear the voice,” which hints at luring singing zombies together—a task that has proven elusive for many.
This puzzle adds depth to the game for completionists but has left even seasoned players stumped. Its complexity highlights Capcom’s willingness to push boundaries in creating challenges that reward dedication and creativity. For gamers passionate about achieving 100% completion, The Final Puzzle represents a significant hurdle that underscores the importance of paying attention to every detail, no matter how small or seemingly unrelated.
Ultimately, The Final Puzzle is a testament to the intricate storytelling and puzzle design in Resident Evil Requiem, offering a unique challenge that resonates with both casual and hardcore gamers. While its difficulty may frustrate some, it also serves as a rewarding testament to the game’s depth and the satisfaction of unraveling its mysteries. For those willing to invest time and effort, The Final Puzzle promises a sense of accomplishment that few other challenges in gaming can match.
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Originally published on PC Gamer on 2/26/2026