Scientists discover 'bacterial constipation,' a new disease caused by gut-drying bacteria

Medical Xpress
February 19, 2026
Scientists at Nagoya University in Japan have found two gut bacteria working together that contribute to chronic constipation. The duo, Akkermansia muciniphila and Bacteroides thetaiotaomicron, destroy the intestinal mucus coating essential for keeping the colon lubricated and feces hydrated. Their excess degradation leaves patients with dry, immobile stool. This discovery, published in Gut Microbes, finally explains why standard treatments often fail for millions of people with chronic constipation.
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Originally published on Medical Xpress on 2/19/2026