Similar kinases play distinct roles in the brain—what this could mean for future therapies
Medical Xpress
February 19, 2026
AI-Generated Deep Dive Summary
Similar though they may appear structurally, MNK1 and MNK2 kinases play unique roles in brain function despite belonging to the same enzyme family. Both are integral to protein synthesis regulation within cells, positioning them as potential targets for treating conditions like epilepsy and chronic pain. However, a recent study reveals that targeting each kinase individually could yield more precise therapeutic outcomes.
The research underscores the distinct functions of MNK1 and MNK2 in brain cells. While MNK1 influences pathways tied to learning and memory by modulating the mTOR pathway, MNK2 affects mechanisms related to neuronal survival under stress. This divergence highlights the importance of selective drug targeting to maximize benefits while minimizing unintended effects.
The study utilized mouse models to demonstrate that inhibiting MNK1 alone reduced seizure activity without impacting pain sensitivity, whereas dual inhibition led to varied and less predictable outcomes. This suggests that future therapies should focus on individual kinases to optimize efficacy and reduce side effects, offering a promising direction for treating nervous system disorders and chronic pain more effectively.
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Originally published on Medical Xpress on 2/19/2026