Single dose of a psychedelic drug can rapidly reduce depressive symptoms, clinical trial suggests
Medical Xpress
February 17, 2026
A single dose of the psychedelic drug dimethyltryptamine (DMT), given with psychological support, rapidly reduced depressive symptoms in 34 adults with major depressive disorder, according to a clinical trial published in Nature Medicine. The improvements, which continued over the ensuing two weeks, suggest that this short-acting treatment could be a more practical therapy compared with other longer-acting psychedelic therapies.
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Originally published on Medical Xpress on 2/17/2026