The key to attacking 'undruggable' proteins: Transient clustering state reveals a moving target

Phys.org

March 3, 2026

Intrinsically disordered proteins lack a fixed structure, which is why they have been considered "undruggable" targets for drug development for years. However, these proteins play a key role in numerous diseases—ranging from various types of cancer to neurodegenerative disorders—long limiting the therapeutic options available to treat them.