The neurobiology of why some brains cannot move on from loss
Medical Xpress
February 18, 2026
For most people, the intense ache that follows the death of a loved one eventually softens, and daily life resumes. But for some, the pain does not ease with time—a condition known as prolonged grief disorder (PGD). In a review published in Trends in Neurosciences, researchers examine what is known about the neurobiology of PGD. The team highlights how disruptions in reward-related brain networks may help explain why grief persists in some individuals and illuminate how PGD differs from depression and anxiety.
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Originally published on Medical Xpress on 2/18/2026