Thunder vs. Pistons odds, prediction, spread, time: 2026 NBA picks for Wednesday, Feb. 25 from proven model

CBS Sports
by Daniel Kohn
February 25, 2026
AI-Generated Deep Dive Summary
Thunder vs. Pistons odds, prediction, spread, time: 2026 NBA picks for Wednesday, Feb. 25 from proven model
The Oklahoma City Thunder and Detroit Pistons are set to clash in a high-stakes NBA game on Wednesday, February 25, with both teams aiming for a strong performance. The Thunder, currently on a three-game winning streak, face the Pistons, who are looking to bounce back from a recent loss. With the Thunder at 45-14 and the Pistons at 42-14, this game promises to be competitive, especially given their respective strengths. The Pistons hold a 7.5-point spread advantage as favorites in this matchup. The Thunder have demonstrated consistency on the road with a 21-7 record, while the Pistons excel at home with a 21-7 mark. Despite these strong performances, both teams are managing injuries. The Thunder's Shai Gilgeous-Alexander, Jalen Williams, and Ajay Mitchell remain out of action, which could impact their lineup. Meanwhile, the Pistons' injury report is yet to be finalized. Chet Holmgren is expected to play a crucial role for the Thunder, averaging 17.8 points in simulations, while Cade Cunningham leads the Pistons with projections of 23.7 points. The game's total point line sits at 221, but the model predicts a combined score of 219, suggesting an under outcome. This aligns with the Pistons' trend of games failing to meet the over/under threshold in 59% of their home contests. The Thunder's balanced attack, including multiple players scoring above double digits, contrasts with the Pistons' more concentrated offensive output led by Cunningham. For sports enthusiasts and bettors, this game offers valuable insights into team dynamics and potential betting opportunities. With the model indicating one side of the spread hitting over 60% of simulations, fans can expect a strategic analysis to guide their decisions. This matchup not only matters for standings but also provides a compelling narrative of skill and strategy. The Thunder vs
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Originally published on CBS Sports on 2/25/2026