UConn vs. St. John's odds, prediction: 2026 college basketball picks for Feb. 25 from proven model

CBS Sports
by Daniel Kohn
February 25, 2026
AI-Generated Deep Dive Summary
UConn vs. St. John's odds, prediction: 2026 college basketball picks for Feb. 25 from proven model
The upcoming college basketball clash between No. 15 St. John's Red Storm and No. 6 Connecticut Huskies is a pivotal matchup in the Big East standings, with first place on the line. Both teams enter the game with strong records, but St. John's boasts an impressive 13-game winning streak, including a dominant road performance against Creighton, while UConn has shown resilience at home, defeating Villanova in their most recent outing. The stakes are high as the Huskies aim to maintain their hold on the top spot, while the Red Storm look to extend their conference dominance. SportsLine's Projection Model has simulated this game 10,000 times and predicts a close contest, with UConn favored by 4.5 points and an over/under total of 146.5 points. The model highlights St. John's strong road performance (8-0 this season) and their ability to secure key defensive stops, which could give them an edge against UConn's balanced attack. On the other hand, the Huskies' home court advantage and their ability to perform under pressure could tilt the scales in their favor. The model also points to a high-scoring game, with the Over hitting in over 60% of simulations. This matchup is significant not only for its impact on the Big East standings but also for the rivalry between these two programs. St. John's has historically fared well against UConn, holding a slight edge in their head-to-head series. However, UConn's recent success at home and their strong defensive performance against Villanova suggest they are prepared to challenge the Red Storm. Fans can expect an intense battle with both teams showcasing their strengths on offense and defense. The game is also of interest to sports bettors, as the model predicts one side of the spread to hit nearly 70% of the time. Additionally, the Over/Under total points line offers
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Originally published on CBS Sports on 2/25/2026