UFC Fight Night predictions -- Sean Strickland vs. Anthony Hernandez: Odds, picks for main event in Houston
CBS Sports
by
Shakiel Mahjouri
February 21, 2026
AI-Generated Deep Dive Summary
A highly anticipated middleweight clash between Sean Strickland and Anthony Hernandez will take center stage at UFC Fight Night in Houston, with the winner potentially securing a strong position for a title shot. Strickland (29-7) seeks to rebound from setbacks and solidify his claim to the top contender spot after Kamaru Usman’s recent rise to the throne. Despite oddsmakers favoring Hernandez (-278), Strickland remains confident, dismissing Hernandez as "not on his level" and aiming to prove his credentials for a championship opportunity.
Hernandez (15-2, 1 NC), known as "Fluffy," has earned eight consecutive wins, including six finishes, putting him on the precipice of an historic three-fight win streak in the middleweight division. A victory over Strickland would not only be his career-defining moment but could position him alongside Nassourdine Imavov as a top contender to the title. Hernandez’s recent remarks highlight his belief that defeating a former champion, like Strickland, would cement his status as a serious threat in the division.
The event also features other notable matchups, such as Geoff Neal (No. 12) facing Uros Medic and Dan Ige (No. 14) taking on Melquizael Costa, both fighters returning after overcoming personal challenges. The card underscores the high stakes of each bout, with fighters determined to prove their mettle in a competitive field.
This event promises to be a pivotal moment for several fighters vying for prominence in the middleweight division and beyond. For sports enthusiasts, it offers a blend of high-stakes rivalries, dramatic comebacks, and the potential for new stars to rise.
Verticals
sports
Originally published on CBS Sports on 2/21/2026